Description

(S)-2-(Pyrrolidin-2-Yl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazole CAS NO 1312547-97-9 is a high-purity, chiral boronic ester derivative of a benzimidazole scaffold. This compound serves as a critical synthetic intermediate in modern organic and medicinal chemistry, enabling the construction of complex molecules through versatile cross-coupling reactions. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams for developing novel active pharmaceutical ingredients (APIs) and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of chiral drug candidates, particularly in kinase inhibitor and antiviral research.
• Suzuki-Miyaura Cross-Coupling: The boronic ester functional group enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides for C-C bond formation.
• Ligand Synthesis: Used in the preparation of novel chiral ligands for asymmetric catalysis.
• Chemical Biology Probes: Serves as a precursor for fluorescent or affinity tags to study biological targets.
• Material Science Research: Potential intermediate for creating organic electronic materials or metal-organic frameworks (MOFs).
• Agrochemical Development: Intermediate in the synthesis of advanced, targeted crop protection agents.

Basic Information

Product Name	(S)-2-(Pyrrolidin-2-Yl)-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Benzo[D]Imidazole
CAS No.	1312547-97-9
Molecular Formula	C17H24BN3O2
Molecular Weight	313.20 g/mol
Synonyms	(S)-6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(pyrrolidin-2-yl)-1H-benzo[d]imidazole; (S)-2-(2-Pyrrolidinyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzimidazole; 1H-Benzimidazole, 2-(2-pyrrolidinyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, (S)-; (S)-2-(Pyrrolidin-2-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzoimidazole; (S)-6-BPin-2-Pyrrolidinylbenzimidazole; (S)-6-(BPin)-2-Pyrrolidinyl-1H-benzimidazole
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. All batches are characterized by advanced analytical techniques including HPLC, NMR, and MS to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, detailing batch-specific results. We adhere to a cGMP-compliant quality management system suitable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a freezer. The container must be kept in a cool, dry, and well-ventilated place. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.