Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-(2,2,2-Trifluoroethyl)Phenyl]- is a high-value, organoboron building block featuring a pinacol-protected boronic ester group and a trifluoroethylphenyl substituent. This compound is critical for enabling advanced cross-coupling reactions, particularly in the synthesis of complex molecules where the trifluoroethyl group imparts desirable physicochemical properties. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-couplings for synthesizing active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoroethyl moiety can improve efficacy and environmental profile.
• Materials Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, where the boronic ester group facilitates precise molecular assembly.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other catalytic processes.
• Fluorine Chemistry: An essential reagent for introducing the 2,2,2-trifluoroethylphenyl group into target molecules, a valuable motif in medicinal and materials chemistry.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological mechanisms and diagnostics.

Basic Information

Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-(2,2,2-Trifluoroethyl)Phenyl]-
CAS No.	1310949-87-1
Molecular Formula	C14H18BF3O2
Molecular Weight	286.10 g/mol
Synonyms	[4-(2,2,2-Trifluoroethyl)phenyl]boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]-1,3,2-dioxaborolane; 2-[4-(2,2,2-Trifluoroethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(2,2,2-Trifluoroethyl)phenylboronic acid pinacol ester; Pinacol [4-(2,2,2-trifluoroethyl)phenyl]boronate; 1,3,2-Dioxaborolane, 4,4,5,5-tetramethyl-2-[4-(2,2,2-trifluoroethyl)phenyl]- (9CI); 4-(Trifluoroethyl)phenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[4-(2,2,2-Trifluoroethyl)Phenyl]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All products undergo rigorous analytical testing, including HPLC, NMR, and GC analysis. Certificates of Analysis (COA) detailing purity and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.