Description

2-(4-(Difluoromethyl)-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it serves as a key intermediate in the development of active ingredients and functional molecules. The CAS number for this compound is provided in the table below.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those containing fluorinated and difluoromethylated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can improve pesticidal activity and environmental profile.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs (Organic Light-Emitting Diodes) and semiconductors, due to its ability to introduce specific aromatic motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Primarily employed as a stable, air-handleable boronate reagent for palladium-catalyzed carbon-carbon bond formation, a cornerstone reaction in medicinal and process chemistry.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific synthesis projects requiring precise fluorinated boronic esters.

Basic Information

Product Name	2-(4-(Difluoromethyl)-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1310949-75-7
Molecular Formula	C13H16B1F3O2
Molecular Weight	272.08 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[4-(difluoromethyl)-3-fluorophenyl]-1,3,2-dioxaborolane; 2-(4-(Difluoromethyl)-3-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-(Difluoromethyl)-3-fluorophenyl)boronic acid pinacol ester; 3-Fluoro-4-(difluoromethyl)phenylboronic acid pinacol ester; Pinacol [4-(difluoromethyl)-3-fluorophenyl]boronate; [4-(Difluoromethyl)-3-fluorophenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 2-(4-(Difluoromethyl)-3-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to prevent hydrolysis and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.