Description

3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2,2-Difluoropropanoic Acid CAS NO 1310680-49-9 is a specialized Fmoc-protected amino acid derivative, a critical building block in modern solid-phase peptide synthesis (SPPS). Its value lies in the unique 2,2-difluoropropanoic acid moiety, which introduces conformational rigidity and metabolic stability into peptide sequences, enabling the development of advanced therapeutic candidates. This high-purity intermediate is essential for research and development scientists in pharmaceutical, biotechnology, and agrochemical sectors focused on creating novel peptide-based drugs and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated, stepwise construction of complex peptides.
• Pharmaceutical R&D: Used to incorporate difluorinated amino acid residues into peptide backbones to enhance drug properties such as bioavailability, proteolytic stability, and target binding affinity.
• Peptidomimetic Design: Serves as a key precursor for creating peptidomimetics, where the difluoro group mimics a transition state or alters electronic properties for improved pharmacological activity.
• Bioconjugation & Probe Development: The carboxylic acid functionality allows for conjugation to other molecules, useful in creating fluorescent probes, affinity labels, or peptide-drug conjugates.
• Agrochemical Research: Applied in the synthesis of bioactive peptide analogs with potential insecticidal or fungicidal properties.
• Academic & Institutional Research: A vital tool for studying structure-activity relationships (SAR) and the effects of fluorination on peptide conformation and function.

Basic Information

Product Name	3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2,2-Difluoropropanoic Acid
CAS No.	1310680-49-9
Molecular Formula	C18H15F2NO4
Molecular Weight	347.31 g/mol
Synonyms	Fmoc-3-amino-2,2-difluoropropanoic acid; Fmoc-A2Fpr-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-2,2-difluoropropanoic acid; 3-[(Fmoc-amino)]-2,2-difluoropropionic acid; 2,2-Difluoro-3-[(9H-fluoren-9-ylmethoxy)formamido]propanoic acid; Fmoc-Difluoroalanine derivative; Fmoc-β,β-difluoroalanine-OH
EINECS	Contact for details

Quality Control

Our production of 3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-2,2-Difluoropropanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. All materials are subjected to comprehensive analytical characterization, including HPLC, NMR, and MS, to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications such as assay, chiral purity, and impurity profiles. We support compliance with cGMP and ISO standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This compound is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to ambient conditions may lead to degradation. For long-term storage, consider desiccation under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.