Description

6-Methyl-1H-Indazole-5-Boronic Acid is a high-purity boronic acid derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in its role as a versatile coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those containing the indazole pharmacophore for oncology, inflammation, and CNS disorders.
• Suzuki-Miyaura Cross-Coupling Reagent: Used extensively in palladium-catalyzed reactions to form carbon-carbon bonds, crucial for creating complex molecular architectures in medicinal chemistry.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Employed in the research and development of organic electronic materials, such as OLEDs and semiconductors, due to its conjugated structure.
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes and affinity ligands for studying biological processes and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and advanced intermediates.

Basic Information

Product Name	6-Methyl-1H-Indazole-5-Boronic Acid
CAS No.	1310405-35-6
Molecular Formula	C8H9BN2O2
Molecular Weight	176.00 g/mol
Synonyms	(6-Methyl-1H-indazol-5-yl)boronic acid; 5-Borono-6-methyl-1H-indazole; 6-Methyl-1H-indazole-5-boronic acid pinacol ester (protected form); 6-Methyl-5-indazoleboronic acid; 1310405-35-6; 6-Methylindazole-5-boronic Acid; 5-(6-Methyl-1H-indazol-5-yl)boronic acid
EINECS	Contact for details

Quality Control

Our 6-Methyl-1H-Indazole-5-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) is provided with every shipment, detailing all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.