Description

2-Chloro-4-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyrimidine is a high-value, organoboron-containing pyrimidine derivative, serving as a critical synthetic intermediate in modern cross-coupling chemistry. Its core value lies in enabling the efficient construction of complex heterocyclic scaffolds, which are fundamental to developing novel active pharmaceutical ingredients (APIs) and advanced materials. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate functionalized pyrimidine motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require specific pyrimidine-based structures for bioactivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes to study biological processes.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	2-Chloro-4-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyrimidine
CAS No.	1310405-15-2
Molecular Formula	C11H18BClN2O2
Molecular Weight	256.54 g/mol
Synonyms	2-Chloro-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-4-methylpyrimidine; 2-Chloro-4-methylpyrimidine-6-boronic acid pinacol ester; 2-Chloro-4-methyl-6-pyrimidineboronic acid pinacol ester; (2-Chloro-4-methylpyrimidin-6-yl)boronic acid pinacol ester; CAS 1310405-15-2; 2-Chloro-4-methyl-6-(pinacolatoboron)pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-4-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Pyrimidine is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard quality commitment includes comprehensive analysis via HPLC, NMR (1H and 13C), and mass spectrometry to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.