Description

4-(Trifluoromethyl)Pyridine-3-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the life sciences sector for constructing complex molecules containing the 4-(trifluoromethyl)pyridine scaffold.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage the trifluoromethylpyridine moiety for enhanced bioactivity and stability.
• Material Science Research: Serves as a building block for creating advanced organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the construction of molecular probes and labeled compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1310405-06-1
Molecular Formula	C₁₃H₁₅BF₃NO₂
Molecular Weight	285.07 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(Trifluoromethyl)pyridine-3-boronic acid pinacol ester; 3-Pyridineboronic acid, 4-(trifluoromethyl)-, 1,1-dimethylethyl ester; Pinacol [4-(trifluoromethyl)pyridin-3-yl]boronate; B-[4-(Trifluoromethyl)-3-pyridinyl]boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for every lot and provided upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.