Description

6-Hydroxypyridine-2-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a key building block in modern synthetic chemistry. Its primary value lies in its dual functionality, serving as a protected boronic acid for Suzuki-Miyaura cross-coupling reactions while also offering a reactive hydroxyl group for further derivatization. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and material science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug candidates, particularly those containing pyridine and biphenyl motifs via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science & OLED Development: Serves as a building block for creating advanced organic electronic materials, such as ligands for metal-organic frameworks (MOFs) and emissive layers in OLEDs.
• Chemical Biology & Probe Design: Utilized in the construction of molecular probes and sensors due to its ability to form stable boronate esters with diols, useful for targeting and detection.
• Academic & Contract Research: A valuable reagent for methodology development and exploring new catalytic transformations in academic and industrial R&D laboratories.

Basic Information

Product Name	6-Hydroxypyridine-2-Boronic Acid Pinacol Ester
CAS No.	1310405-04-9
Molecular Formula	C11H16BNO3
Molecular Weight	221.06 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-hydroxypyridine; 6-Hydroxy-2-pyridineboronic acid pinacol ester; 6-Hydroxy-2-pyridinylboronic acid pinacol ester; 2-(6-Hydroxypyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol 6-hydroxy-2-pyridinylboronate; 6-Hydroxy-2-pyridineboronic acid, pinacol ester; 6-Hydroxypyridine-2-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 6-Hydroxypyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.