Description

4,4,6-Trimethyl-2-(3-Methylphenyl)-1,3,2-Dioxaborinane is a specialized organoboron compound, specifically a cyclic boronic ester, that serves as a versatile intermediate in advanced synthetic chemistry. Its primary value lies in its role as a protected boronic acid derivative, offering enhanced stability and handling characteristics for critical cross-coupling reactions. This high-purity reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional polymers.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key building block for forming carbon-carbon bonds in the synthesis of complex biaryl structures, a common motif in drug discovery.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for creating novel drug candidates with improved efficacy.
• Agrochemical Synthesis: Employed in the production of advanced herbicides, fungicides, and insecticides that require specific, complex aromatic frameworks.
• Materials Science & OLED Development: Acts as a precursor for creating organic electronic materials, such as emissive layers in OLEDs and charge transport materials.
• Ligand and Catalyst Preparation: Useful in the synthesis of sophisticated ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Process Development: Serves as a reliable and stable boronate reagent for method development and scaling up synthetic routes in R&D laboratories.

Basic Information

Product Name	4,4,6-Trimethyl-2-(3-Methylphenyl)-1,3,2-Dioxaborinane
CAS No.	1310404-79-5
Molecular Formula	C14H21BO2
Molecular Weight	232.13 g/mol
Synonyms	2-(3-Methylphenyl)-4,4,6-trimethyl-1,3,2-dioxaborinane; 3-Methylbenzeneboronic acid, cyclic ester with 2,2,4-trimethyl-1,3-pentanediol; (3-Methylphenyl)boronic acid 2,2,4-trimethyl-1,3-pentanediol ester; m-Tolylboronic acid pinacol ester (analogous structure); 3-Methylphenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (common pinacol boronate analog); Boronic ester, cyclic; B-3-Tolyl-4,4,6-trimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 4,4,6-Trimethyl-2-(3-Methylphenyl)-1,3,2-Dioxaborinane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Assay (NMR Titration)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.