Description

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine is a high-value, synthetically versatile organoboron building block, specifically a pyrazine boronic ester. Its core value proposition lies in enabling efficient, palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern pharmaceutical and advanced materials synthesis. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to construct complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing heterocyclic cores prevalent in drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific pyrazine-based structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Chemical Biology & Proteomics: Employed in the development of molecular probes and bioconjugation reagents due to the selective reactivity of the boronic ester group.
• Academic & Contract Research: A critical reagent for methodology development and complex molecule synthesis in academic laboratories and CROs (Contract Research Organizations).
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis under cGMP conditions for advanced pharmaceutical manufacturing.

Basic Information

Product Name	2-Methoxy-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyrazine
CAS No.	1310404-63-7
Molecular Formula	C11H17BN2O3
Molecular Weight	236.08 g/mol
Synonyms	2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine; 5-Methoxy-2-pyrazineboronic acid pinacol ester; 2-Pyrazineboronic acid, 5-methoxy-, 1,1-dimethylethyl ester; 2-Methoxypyrazine-5-boronic acid pinacol ester; 5-Methoxypyrazine-2-boronic acid pinacol ester; Pinacol 2-Methoxy-5-pyrazineboronate; 1310404-63-7
EINECS	Contact for details

Quality Control

Our 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.