Description

2-Chloro-5-Nitropyridine-3-Boronic Acid Pinacol Ester is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex heterocyclic scaffolds. This compound is critically needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the discovery and synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing complex pyridine and bipyridine cores for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used to construct novel herbicide and insecticide molecules by introducing the chloronitropyridine moiety into larger structures via palladium-catalyzed cross-coupling.
• Ligand and Catalyst Development: Serves as a building block for creating sophisticated bidentate and polydentate ligands used in homogeneous catalysis and material science.
• Material Science Research: Employed in the development of organic electronic materials, such as electron-transport layers and non-linear optical (NLO) materials, due to its electron-deficient aromatic system.
• Chemical Biology Probes: Utilized in medicinal chemistry to create tagged molecules and bioconjugates for target identification and binding studies.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	2-Chloro-5-Nitropyridine-3-Boronic Acid Pinacol Ester
CAS No.	1310404-51-3
Molecular Formula	C11H14BClN2O4
Molecular Weight	284.51 g/mol
Synonyms	(2-Chloro-5-nitropyridin-3-yl)boronic acid pinacol ester; 2-Chloro-5-nitro-3-pyridineboronic acid pinacol ester; 3-Boronic acid, 2-chloro-5-nitropyridine-, pinacol ester; 2-Chloro-5-nitropyridine-3-boronic acid neopentyl glycol ester (common alternative); Pinacol (2-chloro-5-nitropyridin-3-yl)boronate; 2-Chloro-5-nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; CAS 1310404-51-3
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Nitropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available for all commercial quantities, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.