Description

2-Bromo-4-Methylpyridine-3-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters because it enables precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyridine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific halogenated pyridine motifs.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysis, and metal-organic frameworks (MOFs).
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron reagent for palladium-catalyzed coupling with various aryl/heteroaryl halides, enabling library synthesis for drug discovery.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	2-Bromo-4-Methylpyridine-3-Boronic Acid Pinacol Ester
CAS No.	1310404-49-9
Molecular Formula	C₁₂H₁₇BBrNO₂
Molecular Weight	298.99 g/mol
Synonyms	2-Bromo-4-methylpyridine-3-boronic acid pinacol ester; (2-Bromo-4-methylpyridin-3-yl)boronic acid pinacol ester; 3-Bromo-4-methylpyridine-2-boronic acid pinacol ester (ambiguous numbering); 2-Bromo-4-methyl-3-pyridineboronic acid pinacol ester; 4-Methyl-2-bromopyridine-3-boronic acid pinacol ester; Pinacol (2-bromo-4-methylpyridin-3-yl)boronate; B-(2-Bromo-4-methyl-3-pyridinyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Bromo-4-Methylpyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive coupling reactions. Each lot is characterized by NMR (¹H, ¹³C, ¹¹B), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and potentially moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.