Description

(4-Bromothiophen-3-Yl)Boronic Acid Pinacol Ester is a high-purity organoboron building block essential for modern synthetic chemistry. This compound is a critical reagent in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for drug discovery and advanced material synthesis.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds, particularly in the synthesis of biaryl and heteroaryl compounds prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, especially those containing functionalized thiophene scaffolds.
• Agrochemical Research: Serves as a building block for creating new herbicides, fungicides, and insecticides with tailored properties.
• Organic Light-Emitting Diode (OLED) Materials: Employed in the synthesis of advanced organic electronic materials and charge-transport layers.
• Ligand and Catalyst Development: Useful for preparing novel boron-containing ligands for catalytic systems and metal-organic frameworks (MOFs).
• Chemical Biology & Probe Development: Facilitates the creation of molecular probes and labeled compounds for biochemical assays and diagnostic applications.

Basic Information

Product Name	(4-Bromothiophen-3-Yl)Boronic Acid Pinacol Ester
CAS No.	1310404-31-9
Molecular Formula	C₁₀H₁₄BBrO₂S
Molecular Weight	289.00 g/mol
Synonyms	4-Bromo-3-thienylboronic acid pinacol ester; 3-Bromo-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; (4-Bromo-3-thienyl)boronic acid pinacol ester; 2-(4-Bromothiophen-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Bromothiophene-3-boronic acid pinacol ester; Pinacol (4-bromothiophen-3-yl)boronate
EINECS	Contact for details

Quality Control

Our (4-Bromothiophen-3-Yl)Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹¹B) and HPLC analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full spectral data are provided to guarantee it meets the high-purity standards required for sensitive coupling reactions and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at room temperature (15-25°C) under an inert atmosphere. This material is moisture-sensitive (hygroscopic) and should be handled in a dry environment to prevent hydrolysis of the boronic ester functionality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.