Description

2-Chloropyrimidine-4-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. This compound matters because it enables precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing pyrimidine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require functionalized pyrimidine structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and advanced polymers.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group protects the boronic acid, enhancing stability and handling for efficient palladium-catalyzed coupling reactions with aryl/heteroaryl halides.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes to study biological processes and protein function.

Basic Information

Product Name	2-Chloropyrimidine-4-Boronic Acid Pinacol Ester
CAS No.	1310404-27-3
Molecular Formula	C11H14BClN2O2
Molecular Weight	252.51 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-(2-chloropyrimidin-4-yl)-1,3,2-dioxaborolane; 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; (2-Chloropyrimidin-4-yl)boronic acid pinacol ester; 2-Chloro-4-pyrimidineboronic acid pinacol ester; 2-Chloro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 1310404-27-3; 2-Chloropyrimidine-4-boronic acid neopentyl glycol ester (common alternative); 2-Chloro-4-boronopyrimidine pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Chloropyrimidine-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We employ advanced analytical techniques including HPLC, NMR, and LC-MS for comprehensive characterization and purity verification. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The container should be kept tightly sealed in a dry inert atmosphere to protect the boronic ester from potential moisture sensitivity and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.