Description

2-Chloro-3-Formylpyridine-4-Boronic Acid Pinacol Ester is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. This compound matters because it combines three distinct reactive handles—a chloro, a formyl, and a boronic ester group—enabling efficient, convergent synthesis of complex molecular architectures. It is primarily needed by pharmaceutical, agrochemical, and advanced materials researchers for constructing novel pyridine-based scaffolds in drug discovery, catalyst development, and functional polymer synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester functionality enables efficient palladium-catalyzed cross-coupling to introduce the pyridine core into complex molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides with pyridine motifs.
• Ligand and Catalyst Development: Serves as a building block for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, metal-organic frameworks (MOFs), and other functional materials.
• Chemical Biology Probes: Useful for creating tagged molecules and probes for studying biological pathways and target engagement.

Basic Information

Product Name	2-Chloro-3-Formylpyridine-4-Boronic Acid Pinacol Ester
CAS No.	1310404-21-7
Molecular Formula	C₁₃H₁₅BClNO₃
Molecular Weight	279.52 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloropyridine-3-carboxaldehyde; 2-Chloro-3-formyl-4-pyridinylboronic acid pinacol ester; 2-Chloro-3-formylpyridine-4-boronic acid pinacol ester; 2-Chloro-3-pyridinecarboxaldehyde-4-boronic acid pinacol ester; (2-Chloro-3-formylpyridin-4-yl)boronic acid pinacol ester; 4-Borono-2-chloronicotinaldehyde pinacol ester; 1310404-21-7
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Formylpyridine-4-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) with full specification data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.