Description

Ethynylboronic Acid Mida Ester is a specialized, high-value organoboron reagent featuring the N-methyliminodiacetic acid (MIDA) protecting group. This compound is critically important for enabling robust, iterative cross-coupling reactions, particularly in complex molecule synthesis where traditional boronic acids may be unstable. It is an essential building block for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors, facilitating the precise and efficient construction of carbon-carbon bonds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant boron reagent for palladium-catalyzed couplings with aryl/vinyl halides.
• Iterative Synthesis Platforms: Enables automated, multi-step synthesis of complex polyenes, conjugated polymers, and natural product analogs due to its slow-release properties.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), especially those containing acetylene or complex olefin motifs.
• Agrochemical Synthesis: A key precursor for creating novel fungicides, herbicides, and insecticides with tailored properties.
• Materials Science Research: Building block for synthesizing organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Probe Development: Utilized in the synthesis of bioconjugates and molecular probes for studying biological systems.

Basic Information

Product Name	Ethynylboronic Acid Mida Ester
CAS No.	1310384-76-9
Molecular Formula	C9H12BNO4
Molecular Weight	209.01 g/mol
Synonyms	Ethynylboronic Acid MIDA Ester; (Ethynyl)-MIDA-boronate; N-Methyliminodiacetic Acid Ethynylboronate; B-Ethynyl-5,5-dimethyl-1,3,2-dioxaborinane-4,6-dione?; Ethynyl MIDA Boronate; 2-(Ethynyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methylacetamide (common misassignment); Acetylene MIDA Boronate; CAS 1310384-76-9.
EINECS	Contact for details

Quality Control

Our Ethynylboronic Acid Mida Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality management system is designed to meet the stringent requirements of research and development laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may require storage under an inert atmosphere for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.