Description

5-Fluoro-6-Methoxypyridine-3-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a critical step for constructing complex biaryl and heterobiaryl structures prevalent in modern drug discovery. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and antiviral research programs.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Serves as a precursor for organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a boronic ester coupling partner to introduce the 5-fluoro-6-methoxypyridin-3-yl moiety into complex molecules.
• Library Synthesis for Drug Discovery: Enables high-throughput parallel synthesis to create diverse compound libraries for screening against biological targets.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organometallic chemistry.

Basic Information

Product Name	5-Fluoro-6-Methoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	1310384-35-0
Molecular Formula	C₁₂H₁₇BFNO₃
Molecular Weight	253.08 g/mol
Synonyms	5-Fluoro-6-methoxypyridine-3-boronic acid pinacol ester; (5-Fluoro-6-methoxypyridin-3-yl)boronic acid pinacol ester; 3-Borono-5-fluoro-6-methoxypyridine pinacol ester; 5-Fluoro-6-methoxy-3-pyridineboronic acid pinacol ester; 2-(5-Fluoro-6-methoxypyridin-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1310384-35-0; 5-Fluoro-6-methoxy-3-pyridinylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Fluoro-6-Methoxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.