Description

tert-Butyl 4-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-yl)phenoxymethyl]piperidine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold and a pinacol boronate ester functional group. This compound is critically important for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting G-protein coupled receptors (GPCRs) and kinase inhibitors.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation to create complex biaryl and heterobiaryl systems.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds and molecular probes for target identification and validation studies.

Basic Information

Item	Details
Product Name	tert-Butyl 4-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-yl)phenoxymethyl]piperidine-1-carboxylate
CAS No.	1310383-45-9
Molecular Formula	C23H36BNO5
Molecular Weight	417.35 g/mol
Synonyms	1-Boc-4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxymethyl]piperidine; tert-Butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)methyl)piperidine-1-carboxylate; 1,3,2-Dioxaborolane, 2-[4-[[1-[(1,1-dimethylethoxy)carbonyl]-4-piperidinyl]methoxy]phenyl]-4,4,5,5-tetramethyl-; 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxymethyl]piperidine-1-carboxylic acid tert-butyl ester; BOC-Piperidine-4-CH2-O-Ph-Bpin; 1310383-45-9
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-yl)phenoxymethyl]piperidine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H and 13C), and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.