Description

2-(3-Fluorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling Suzuki-Miyaura cross-coupling reactions, a pivotal method for forming carbon-carbon bonds with high efficiency and functional group tolerance. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used to create novel fluorinated herbicides, fungicides, and insecticides with enhanced properties.
• Material Science Research: Building block for constructing fluorinated organic electronic materials, such as OLEDs and semiconductors.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-handleable boronic ester partner for palladium-catalyzed aryl-aryl bond formation.
• Chemical Biology Probes: Utilized in the development of fluorinated probes and ligands for target identification and binding studies.
• Fine Chemical Production: Intermediate for manufacturing specialty fluorinated aromatics used in flavors, fragrances, and dyes.

Basic Information

Product Name	2-(3-Fluorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1310048-95-3
Molecular Formula	C13H18BFO2
Molecular Weight	236.09 g/mol
Synonyms	(3-Fluorobenzyl)boronic acid pinacol ester; 1-(3-Fluorophenyl)-N-methoxymethanamine pinacol boronate; 3-Fluorobenzylboronic acid pinacol ester; (3-Fluorobenzyl)BPin; 2-[(3-Fluorophenyl)methyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluorobenzyl MIDA Boronate (related precursor); 3-Fluorobenzyl Trifluoroborate (alternative form).
EINECS	Contact for details

Quality Control

Our 2-(3-Fluorobenzyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is analyzed via NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to confirm identity and purity. Certificates of Analysis (COA) with full analytical data are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic (moisture-sensitive) nature. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95% (Typical 97-99%)
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.