Description

5-tert-Butyloxycarbonylamino-2-Methoxypyridine-3-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. Its core value lies in enabling efficient, selective cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are fundamental for constructing complex molecular architectures. This advanced intermediate is primarily needed by pharmaceutical R&D and fine chemical synthesis teams for the development of active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting heterocyclic scaffolds.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for forming carbon-carbon bonds between aromatic and heteroaromatic systems under mild conditions.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides that require specific pyridine-based structures.
• Material Science Research: Employed in the creation of organic electronic materials, ligands for catalysts, and other functional organic compounds.
• Process Chemistry & Scale-up: Suitable for use in route development and pilot-scale synthesis due to its stability and handling properties compared to free boronic acids.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) exploring new synthetic methodologies and compound libraries.

Basic Information

Product Name	5-tert-Butyloxycarbonylamino-2-Methoxypyridine-3-Boronic Acid Pinacol Ester
CAS No.	1309982-65-7
Molecular Formula	C17H27BN2O5
Molecular Weight	350.22 g/mol
Synonyms	5-((tert-Butoxycarbonyl)amino)-2-methoxypyridine-3-boronic acid pinacol ester; 3-Borono-5-((tert-butoxycarbonyl)amino)-2-methoxypyridine pinacol ester; Boc-protected 5-amino-2-methoxy-3-pyridineboronic acid pinacol ester; 5-(Boc-amino)-2-methoxypyridine-3-boronic acid pinacol ester; N-Boc-5-amino-2-methoxy-3-pyridineboronic acid pinacol ester; 2-Methoxy-5-((tert-butoxycarbonyl)amino)pyridine-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-tert-Butyloxycarbonylamino-2-Methoxypyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.