Description

4-(1-Pyrrolidinyl)Phenylboronic Acid Hcl is a specialized boronic acid derivative, a key building block in modern synthetic chemistry. This compound matters for its role as a crucial coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. Pharmaceutical researchers and fine chemical manufacturers need it for the development of active pharmaceutical ingredients (APIs) and advanced organic materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid reagent for forming carbon-carbon bonds in medicinal chemistry and material science research.
• Ligand Synthesis: Used in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the development of molecular probes for studying biological pathways and protein interactions.
• Advanced Material Development: A building block for creating organic electronic materials and functional polymers.
• Process Chemistry & Scale-up: Suitable for use in process optimization and the pilot-scale manufacturing of target molecules.

Basic Information

Product Name	4-(1-Pyrrolidinyl)Phenylboronic Acid Hcl
CAS No.	1309982-59-9
Molecular Formula	C10H14BNO2 • HCl
Molecular Weight	227.50 g/mol (Free base: 190.04 g/mol)
Synonyms	4-(Pyrrolidin-1-yl)phenylboronic acid hydrochloride; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrrolidine hydrochloride; 4-(N-Pyrrolidino)benzeneboronic acid HCl; 4-Pyrrolidin-1-ylbenzeneboronic acid hydrochloride; B-[4-(1-Pyrrolidinyl)phenyl]boronic acid hydrochloride; 4-(1-Pyrrolidinyl)benzeneboronic acid HCl salt
EINECS	Contact for details

Quality Control

Our 4-(1-Pyrrolidinyl)Phenylboronic Acid Hcl is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.