Description

5-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-value organoboron building block, specifically a protected aniline boronic ester derivative. This compound is critical for modern synthetic chemistry, enabling efficient cross-coupling reactions to construct complex molecules. It is primarily utilized by pharmaceutical, agrochemical, and advanced materials research and development teams for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated biaryl compounds, which are prevalent in drug discovery for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used to create novel fluorinated pesticides and herbicides, leveraging the fluorine atom's ability to enhance biological activity, metabolic stability, and membrane permeability.
• Material Science Research: Serves as a monomer or building block for developing organic electronic materials, such as polymers for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis or as a scaffold for creating boron-containing metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to synthesize fluorinated probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	5-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	1309982-16-8
Molecular Formula	C12H17BFNO2
Molecular Weight	237.08 g/mol
Synonyms	2-Amino-4-fluorophenylboronic acid pinacol ester; 5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; (2-Amino-4-fluorophenyl)boronic acid pinacol ester; 4-Fluoro-2-(pinacolatoboryl)aniline; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluoroaniline; 5-Fluoro-2-(pinacolatoboryl)aniline; 2-Amino-4-fluorobenzene-1-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can support customer-specific analytical requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.