Description

Boc-3-Amino-6-Methylpyridine-2-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid ester building block essential for modern cross-coupling reactions in medicinal chemistry and material science. Its value lies in providing a stable, reactive handle for Suzuki-Miyaura couplings while protecting the amine functionality, enabling precise and complex molecular construction. This compound is critically needed by pharmaceutical R&D teams, agrochemical developers, and advanced material scientists for synthesizing novel heterocyclic compounds, active pharmaceutical ingredients (APIs), and functional organic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable organoboron reagent for forming carbon-carbon bonds to construct complex biaryl and heterobiaryl structures.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides with targeted activity.
• Material Science & OLED Development: A precursor for creating organic electronic materials, ligands for catalysts, and emissive layers in display technologies.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Facilitates the modular assembly of bifunctional molecules for targeted protein degradation.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.

Basic Information

Product Name	Boc-3-Amino-6-Methylpyridine-2-Boronic Acid Pinacol Ester
CAS No.	1309981-41-6
Molecular Formula	C17H27BN2O4
Molecular Weight	334.22 g/mol
Synonyms	2-[(3,3-Dimethylbutane-1,3-diyl)oxy]-6-methyl-3-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-boronic Acid; tert-Butyl N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-methylpyridin-3-yl]carbamate; 3-((tert-Butoxycarbonyl)amino)-6-methylpicolinboronic Acid Pinacol Ester; Boc-3-Amino-6-Methylpicolinboronic Acid Pinacol Ester; 3-(Boc-amino)-6-methylpyridine-2-boronic Acid Pinacol Ester; 2-Borono-6-methyl-3-[(tert-butoxycarbonyl)amino]pyridine Pinacol Ester; 1309981-41-6; BOC-3-AMINO-6-METHYLPYRIDINE-2-BORONIC ACID PINACOL ESTER
EINECS	Contact for details

Quality Control

Our Boc-3-Amino-6-Methylpyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and chemical identity consistent with pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.