Description

3-Fluoro-4-Methylpyridine-2-Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and agrochemical development. This compound is specifically engineered for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing fluorinated pyridine motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and metabolic stability.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed coupling with aryl/heteroaryl halides to create biaryl structures.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Useful for creating molecular probes and bioconjugates for target identification and binding studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring specialized boronic acid derivatives.

Basic Information

Product Name	3-Fluoro-4-Methylpyridine-2-Boronic Acid Pinacol Ester
CAS No.	1309981-40-5
Molecular Formula	C₁₂H₁₇BFNO₂
Molecular Weight	237.08 g/mol
Synonyms	2-(3-Fluoro-4-methylpyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-4-methylpyridine-2-boronic acid pinacol ester; 2-(3-Fluoro-4-methyl-2-pyridinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Fluoro-4-methyl-2-pyridineboronic acid pinacol ester; (3-Fluoro-4-methylpyridin-2-yl)boronic acid pinacol ester; Pinacol (3-fluoro-4-methylpyridin-2-yl)boronate
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methylpyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.