Description

6-(Piperazin-1-Yl)Pyridine-2-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative crucial for modern synthetic chemistry. This compound serves as a key building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for drug discovery and process chemistry applications.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, where its piperazine-pyridine scaffold is incorporated for bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Employed in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic research.
• Material Science Research: Utilized in the development of organic electronic materials and polymers due to its conjugated system and functional handle.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	6-(Piperazin-1-Yl)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1309981-38-1
Molecular Formula	C15H24BN3O2
Molecular Weight	289.18 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(piperazin-1-yl)pyridine; 6-Piperazin-1-ylpyridine-2-boronic acid pinacol ester; 2-(Piperazin-1-yl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 6-(1-Piperazinyl)-2-pyridineboronic acid pinacol ester; 1309981-38-1; AKOS025311321; BRN 15321335; FT-0698395
EINECS	Contact for details

Quality Control

Our 6-(Piperazin-1-Yl)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.