Description

n-(2-Bromo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Pivalamide is a high-value, multi-functional organic building block that combines a halogenated pyridine core with a protected boronic ester group. This molecular architecture makes it a critical intermediate for constructing complex molecules via cross-coupling reactions, such as the Suzuki-Miyaura reaction. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, ligands for catalysts, and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: The pinacol boronic ester functionality is specifically designed for efficient Suzuki-Miyaura cross-coupling with various aryl/heteroaryl halides.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and bioconjugates for target identification and binding studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	n-(2-Bromo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Pivalamide
CAS No.	1309980-68-4
Molecular Formula	C16H24BBrN2O3
Molecular Weight	383.09 g/mol
Synonyms	2-Bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2-dimethylpropanoyl)pyridin-3-amine; 3-Amino-2-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine Pivalamide; 2-Bromo-5-(pinacolatoboryl)-N-pivaloylpyridin-3-amine; Pivalamide, N-[2-bromo-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]-; 1309980-68-4; 2-Bromo-5-(pinacolboron)pyridine-3-pivalamide; Boronic acid, B-[6-bromo-5-[(2,2-dimethyl-1-oxopropyl)amino]-3-pyridinyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our n-(2-Bromo-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl)Pivalamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the primary container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.