Description

n-[5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridyl]-2,2-Dimethyl-Propanamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester group, a critical functional handle for modern cross-coupling reactions. This compound is essential for the efficient synthesis of complex molecules, enabling the rapid construction of carbon-carbon bonds under mild conditions. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery and scale-up of new active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing coupling partner for the synthesis of biaryl and heterobiaryl structures prevalent in drug candidates.
• Pharmaceutical Intermediate: Used in the research, development, and production of active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Employed in the creation of novel herbicides, fungicides, and insecticides that require complex, fluorinated heterocyclic cores.
• Material Science Research: Acts as a building block for organic electronic materials, such as those used in OLEDs and organic photovoltaics, where precise molecular architecture is required.
• Chemical Biology & Proteomics: Utilized as a probe or linker in the development of chemical tools for studying biological systems and protein function.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis organizations (CSOs) and CDMOs serving the global life sciences market.

Basic Information

Item	Detail
Product Name	n-[5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridyl]-2,2-Dimethyl-Propanamide
CAS No.	1309980-31-1
Molecular Formula	C16H24BFN2O3
Molecular Weight	322.19 g/mol
Synonyms	2,2-Dimethyl-N-[5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]propanamide; 5-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2-dimethylpropanoyl)pyridin-2-amine; 1309980-31-1; 2-Pyridinepropanamide, N-[5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-2,2-dimethyl-; Boronic acid, B-[6-[[(2,2-dimethyl-1-oxopropyl)amino]-5-fluoro-3-pyridinyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our n-[5-Fluoro-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2-Pyridyl]-2,2-Dimethyl-Propanamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.