Description

8-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine CAS NO 1309980-14-0 is a high-purity, advanced pharmaceutical intermediate belonging to the class of heterocyclic boronic acid pinacol esters. This compound is a critical building block in modern organic synthesis, valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Suzuki-Miyaura Cross-Coupling: Essential boron reagent for forming carbon-carbon bonds in the construction of biaryl and heterobiaryl structures under mild conditions.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science: Building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & Contract Research: Serves as a versatile starting material for methodological development and discovery chemistry in R&D laboratories.

Basic Information

Product Name	8-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine
CAS No.	1309980-14-0
Molecular Formula	C15H20BNO4
Molecular Weight	289.14 g/mol
Synonyms	2,3-Dihydro-[1,4]dioxino[2,3-b]pyridine-8-boronic acid pinacol ester; 8-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1,4-dioxino[2,3-b]pyridine; 1,4-Dioxino[2,3-b]pyridine-8-boronic acid, 2,3-dihydro-, pinacol ester; 8-Boronic acid-2,3-dihydro-1,4-dioxino[2,3-b]pyridine pinacol ester; 8-(Pinacolboranyl)-2,3-dihydro-1,4-dioxino[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 8-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-2,3-Dihydro-[1,4]Dioxino[2,3-B]Pyridine adheres to stringent quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment supports applications requiring GMP-grade materials for preclinical and clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening to prevent degradation. For long-term storage, consider storing desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.