Description

Benzamide, n-(1,1-Dimethylethyl)-3-Nitro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, multi-functional organic building block that combines a benzamide core with a nitro group and a pinacol boronate ester. This compound matters because its unique structure provides two distinct reactive handles, enabling its use as a versatile intermediate in complex organic synthesis, particularly for constructing novel molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, cross-coupling reactions, and the development of active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially for creating complex molecules via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require specific benzamide-based scaffolds.
• Material Science: Serves as a precursor for organic electronic materials, such as those used in OLEDs or organic semiconductors, where the boronate ester enables polymerization or functionalization.
• Chemical Synthesis: Utilized in palladium-catalyzed cross-coupling reactions to form new carbon-carbon bonds, a fundamental transformation in modern organic chemistry.
• Ligand and Catalyst Development: The amide and nitro functional groups can be modified to create novel ligands for metal catalysts or organocatalysts.
• Academic & Contract Research: Essential for synthetic chemistry research in universities and CROs (Contract Research Organizations) exploring new reaction methodologies.

Basic Information

Product Name	Benzamide, n-(1,1-Dimethylethyl)-3-Nitro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1309980-13-9
Molecular Formula	C17H25BN2O5
Molecular Weight	348.20 g/mol
Synonyms	N-tert-Butyl-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 3-Nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(tert-butyl)benzamide; N-(tert-Butyl)-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 5-Boronic acid, N-(1,1-dimethylethyl)-3-nitrobenzamide, pinacol ester; 1309980-13-9; tert-Butyl 3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide
EINECS	Contact for details

Quality Control

Our Benzamide, n-(1,1-Dimethylethyl)-3-Nitro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with exacting R&D and process chemistry standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.