Description

2-Iodo-3,3,3-Trifluoropropyl Chlorosulfate is a specialized organofluorine and organoiodine building block of significant interest in advanced synthetic chemistry. This compound matters for its unique bifunctional reactivity, combining a chlorosulfate leaving group with an iodo-trifluoropropyl moiety, enabling precise molecular construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel fluorinated target molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the introduction of a trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a critical intermediate in the production of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Polymer Modification: Employed to introduce fluorinated segments into polymer backbones, imparting valuable characteristics such as oil/water repellency, chemical resistance, and low surface energy.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) due to the reactive carbon-iodine bond.
• Radical Chemistry: Utilized as a source of trifluoromethyl and iodinated radicals in radical addition and cyclization reactions for constructing complex organic frameworks.

Basic Information

Product Name	2-Iodo-3,3,3-Trifluoropropyl Chlorosulfate
CAS No.	1309602-68-3
Molecular Formula	C3H3ClF3IO3S
Molecular Weight	345.47 g/mol
Synonyms	3,3,3-Trifluoro-2-iodopropyl chlorosulfate; 1-Chlorosulfonyloxy-3,3,3-trifluoro-2-iodopropane; 2-Iodo-1-propanol, 3,3,3-trifluoro-, 1-(chlorosulfate); Chlorosulfuric Acid 3,3,3-Trifluoro-2-iodopropyl Ester; Iodotrifluoropropyl Chlorosulfate
EINECS	Contact for details

Quality Control

Our 2-Iodo-3,3,3-Trifluoropropyl Chlorosulfate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is analyzed using advanced techniques including NMR (¹H, ¹⁹F, ¹³C), HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.