Description

Ethyl 3-Chloro-4,4,4-Trifluorobutyrate is a high-value fluorinated organic ester, serving as a critical building block in advanced chemical synthesis. Its molecular structure, featuring both chloro and trifluoromethyl groups, makes it a versatile intermediate for introducing fluorine atoms into target molecules, a key strategy for modulating the properties of pharmaceuticals and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating novel compounds with enhanced bioactivity, metabolic stability, and physical characteristics.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of molecules containing a β-trifluoromethyl-β-chloro ethyl ester moiety.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the introduction of fluorine improves efficacy and environmental profile.
• Fluorinated Building Block: Essential for medicinal chemistry and drug discovery programs aiming to improve drug lipophilicity, metabolic stability, and membrane permeability through strategic fluorination.
• Organic Synthesis Reagent: Employed in various organic transformations, including nucleophilic substitutions and coupling reactions, to construct complex fluorinated architectures.
• Material Science Research: Potential intermediate in the development of fluorinated polymers, liquid crystals, or specialty coatings with unique surface properties.

Basic Information

Product Name	Ethyl 3-Chloro-4,4,4-Trifluorobutyrate
CAS No.	1309602-63-8
Molecular Formula	C6H8ClF3O2
Molecular Weight	204.58 g/mol
Synonyms	3-Chloro-4,4,4-trifluorobutanoic Acid Ethyl Ester; Ethyl 3-Chloro-4,4,4-trifluorobutanoate; Butanoic acid, 3-chloro-4,4,4-trifluoro-, ethyl ester; 1309602-63-8; Ethyl 3-chloro-4,4,4-trifluorobutyrate; 4,4,4-Trifluoro-3-chlorobutanoic acid ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 3-Chloro-4,4,4-Trifluorobutyrate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use and stored away from heat, sparks, and open flames. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.390 - 1.400
Density (g/mL at 20°C)	1.30 - 1.35

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.