Description

5-(Hydroxymethyl)Pyridine-2-Boronic Acid Pinacol Ester is a high-value boronic ester building block crucial for modern synthetic chemistry. This compound matters because it enables the precise construction of complex molecules through reliable cross-coupling reactions, such as the Suzuki-Miyaura reaction. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing new active ingredients, functional polymers, and electronic materials. Its bifunctional hydroxymethyl and boronic ester groups offer versatile handles for further chemical elaboration.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in constructing complex heterocyclic scaffolds for next-generation herbicides, fungicides, and insecticides.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized pyridine-based ligands used in homogeneous catalysis.
• Material Science: Employed in the synthesis of functionalized polymers, organic semiconductors, and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: Primarily designed as a stable, air-handleable reagent for Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl linkages.

Basic Information

Item	Details
Product Name	5-(Hydroxymethyl)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1309601-94-2
Molecular Formula	C13H20BNO3
Molecular Weight	249.12 g/mol
Synonyms	2-(5-(Hydroxymethyl)pyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-(Hydroxymethyl)-2-pyridineboronic acid pinacol ester; (5-(Hydroxymethyl)pyridin-2-yl)boronic acid pinacol ester; 2-(5-Hydroxymethyl-2-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Hydroxymethyl-2-pyridylboronic acid pinacol ester; Pinacol [5-(hydroxymethyl)pyridin-2-yl]boronate
EINECS	Contact for details

Quality Control

Our 5-(Hydroxymethyl)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including NMR (1H, 13C, 11B), HPLC for purity assessment, and mass spectrometry for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to ensure full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.