Description

1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[(1R,2S)-2-Methylcyclopropyl]-, Rel- is a high-purity, chiral organoboron reagent essential for advanced synthetic chemistry. This compound is a key building block for the stereoselective synthesis of complex molecules, offering precise control over three-dimensional structure. It is primarily utilized by research institutions and pharmaceutical companies in the development of active pharmaceutical ingredients (APIs) and novel agrochemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A crucial reagent for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate Synthesis: Used in the stereoselective construction of chiral centers for potential drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research & Development: Serves as a key precursor in creating novel, stereochemically defined pesticides and herbicides.
• Material Science: Employed in the synthesis of organic electronic materials and liquid crystals where specific stereochemistry influences material properties.
• Asymmetric Synthesis Catalysis: Acts as a chiral ligand precursor or a transfer agent in catalytic asymmetric transformations.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[(1R,2S)-2-Methylcyclopropyl]-, Rel-
CAS No.	1309366-00-4
Molecular Formula	C10H19BO2
Molecular Weight	182.07 g/mol
Synonyms	Rel-((1R,2S)-2-Methylcyclopropyl)boronic acid pinacol ester; (1R,2S)-2-Methylcyclopropaneboronic acid pinacol ester; (1R,2S)-2-Methylcyclopropylboronic acid pinacol ester; (1R,2S)-2-Methylcyclopropyl-Bpin; trans-2-Methylcyclopropylboronic acid pinacol ester; Pinacol (1R,2S)-2-methylcyclopropylboronate; 4,4,5,5-Tetramethyl-2-[(1R,2S)-2-methylcyclopropyl]-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 4,4,5,5-Tetramethyl-2-[(1R,2S)-2-Methylcyclopropyl]-, Rel- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and GC analysis, to ensure high chemical and enantiomeric purity suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.