Description

1-tert-Butyl 4-Ethyl 3,3-Difluoropiperidine-1,4-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a difluorinated piperidine core. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules where the introduction of fluorine atoms can dramatically alter pharmacokinetic properties. It is primarily sought after by R&D teams and process chemists in the pharmaceutical and agrochemical industries for constructing complex, fluorinated target structures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to incorporate fluorine for improved metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Serves as a precursor in the development of new-generation fluorinated pesticides and herbicides.
• Fluorine Chemistry: A valuable reagent for exploring new fluorination methodologies and creating fluorinated compound libraries.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific fluorinated molecules.

Basic Information

Product Name	1-tert-Butyl 4-Ethyl 3,3-Difluoropiperidine-1,4-Dicarboxylate
CAS No.	1303972-95-3
Molecular Formula	C13H21F2NO4
Molecular Weight	293.31 g/mol
Synonyms	1-tert-Butoxycarbonyl-4-ethoxycarbonyl-3,3-difluoropiperidine; 3,3-Difluoropiperidine-1,4-dicarboxylic acid 1-tert-butyl 4-ethyl ester; tert-Butyl 4-ethoxycarbonyl-3,3-difluoropiperidine-1-carboxylate; 1-Boc-4-(ethoxycarbonyl)-3,3-difluoropiperidine; Boc-3,3-difluoropiperidine-4-carboxylic acid ethyl ester; Ethyl 1-Boc-3,3-difluoropiperidine-4-carboxylate; 3,3-Difluoro-1,4-piperidinedicarboxylic acid 1-(1,1-dimethylethyl) 4-ethyl ester
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 4-Ethyl 3,3-Difluoropiperidine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.