Description

3-Methyl-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is a high-value, multi-functional heterocyclic building block that combines an indole scaffold with a pinacol boronate ester group. This molecular architecture makes it a critical intermediate for modern synthetic methodologies, particularly in the construction of complex pharmaceutical and agrochemical candidates. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in cross-coupling reactions and medicinal chemistry.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boron-containing coupling partner for the synthesis of biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Employed in creating advanced fungicides, herbicides, and insecticides with improved efficacy and environmental profiles.
• Material Science Research: Acts as a precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized as a versatile linker or functional group in the design of bifunctional molecules for targeted protein degradation.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for hit identification and lead optimization in drug discovery campaigns.

Basic Information

Product Name	3-Methyl-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole
CAS No.	1300582-52-8
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	3-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-1H-indole; 3-Methyl-1H-indole-6-boronic acid pinacol ester; 3-Methylindole-6-boronic acid pinacol ester; 6-Borono-3-methylindole pinacol ester; CAS 1300582-52-8
EINECS	Contact for details

Quality Control

Our 3-Methyl-6-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.