Description

1-(5-Fluoro-2-Hydroxyphenyl)-2-(3-Fluorophenyl)Ethanone is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its specific difluorinated structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to innovate new molecular entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in therapeutic areas requiring fluorinated scaffolds for enhanced potency and pharmacokinetic properties.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where fluorine atoms improve efficacy and environmental profile.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers and advanced organic materials with unique optical or electronic properties.
• Chemical Biology & Probe Development: Employed in the design and synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(5-Fluoro-2-Hydroxyphenyl)-2-(3-Fluorophenyl)Ethanone
CAS No.	1300582-07-3
Molecular Formula	C14H10F2O2
Molecular Weight	248.23 g/mol
Synonyms	3'-Fluoro-2'-hydroxy-5-fluorochalcone; 1-(5-Fluoro-2-hydroxyphenyl)-2-(3-fluorophenyl)ethan-1-one; 2-Hydroxy-5-fluoro-3'-fluorochalcone; 3-Fluorophenyl 5-fluoro-2-hydroxyphenyl ketone; (3-Fluorophenyl)(5-fluoro-2-hydroxyphenyl)methanone (tautomer); 2'-Hydroxy-5-fluoro-3-fluorochalcone; Difluorinated Hydroxychalcone Intermediate
EINECS	Contact for details

Quality Control

Our 1-(5-Fluoro-2-Hydroxyphenyl)-2-(3-Fluorophenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. Certificates of Analysis (COA) with full analytical data are provided to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.