Description

2-[5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Propan-2-Ol is a high-value, protected boronic ester derivative that serves as a critical synthetic intermediate. This compound is essential for facilitating efficient cross-coupling reactions, enabling the construction of complex molecular architectures with precision. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides, where the pyridine-boronate moiety is integral to biological activity.
• Material Science Research: Employed in the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, due to its functional handle for polymerization or functionalization.
• Chemical Biology & Probe Development: Serves as a precursor for creating bioconjugation reagents and molecular probes used in diagnostic assays and cellular imaging studies.
• Catalyst Ligand Precursor: Can be utilized to synthesize novel ligand frameworks for transition metal catalysts used in asymmetric synthesis and other catalytic processes.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific boronic ester functionalities.

Basic Information

Product Name	2-[5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Propan-2-Ol
CAS No.	1300118-52-8
Molecular Formula	C14H22BNO3
Molecular Weight	263.14 g/mol
Synonyms	2-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)propan-2-ol; 2-(5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl)propan-2-ol; 2-(5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl)-2-propanol; 2-Propan-2-ol-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol ester of 6-(2-Hydroxypropan-2-yl)pyridine-3-boronic acid
EINECS	Contact for details

Quality Control

Our production of 2-[5-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-2-Yl]Propan-2-Ol adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical characterization, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.