Description

Methyl 7-Iodo-2,2-Difluoro-1,3-Benzodioxole-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its unique halogenated benzodioxole structure. This compound is a critical building block for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in areas targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Research: Serves as a precursor in the synthesis of new-generation herbicides, fungicides, and insecticides, leveraging the difluoro and iodo substituents for bioactivity.
• Material Science: Used in the research and development of specialty polymers and liquid crystals, where the benzodioxole core can impart specific electronic or structural properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille) due to the reactive iodo group, enabling the construction of complex aromatic systems.
• Fluorine Chemistry Studies: Acts as a valuable substrate for studying the influence of gem-difluoro motifs on molecular conformation and metabolic stability in drug design.

Basic Information

Product Name	Methyl 7-Iodo-2,2-Difluoro-1,3-Benzodioxole-5-Carboxylate
CAS No.	1298047-55-8
Molecular Formula	C9H5F2IO4
Molecular Weight	341.04 g/mol
Synonyms	Methyl 7-iodo-2,2-difluoro-1,3-benzodioxole-5-carboxylate; 5-Carbomethoxy-7-iodo-2,2-difluoro-1,3-benzodioxole; 7-Iodo-2,2-difluoro-1,3-benzodioxole-5-carboxylic acid methyl ester; Methyl 7-iodo-2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 7-Iodo-2,2-Difluoro-1,3-Benzodioxole-5-Carboxylate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.