Description

(2S)-5-Oxo-2-Pyrrolidinecarbothioic Acid S-Ethyl Ester is a high-purity chiral building block and synthetic intermediate of significant value in advanced organic synthesis. Its defined stereochemistry and functionalized pyrrolidinone core make it a critical precursor for the development of novel pharmaceutical compounds and bioactive molecules. This product is essential for research and production chemists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate complex, stereodefined heterocyclic structures into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of potential drug candidates, particularly those targeting neurological disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of novel, stereospecific pesticides and herbicides where specific chirality can influence biological activity.
• Fine Chemical Synthesis: Serves as a versatile building block for creating complex natural product analogs and specialty chemicals.
• Asymmetric Catalysis Ligand Precursor: Can be utilized in the preparation of chiral ligands or catalysts for enantioselective transformations.
• Peptidomimetic Research: Its structure is valuable for constructing peptidomimetics and conformationally constrained amino acid derivatives.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new synthetic routes involving γ-lactam scaffolds.

Basic Information

Product Name	(2S)-5-Oxo-2-Pyrrolidinecarbothioic Acid S-Ethyl Ester
CAS No.	1298024-11-9
Molecular Formula	C7H11NO2S
Molecular Weight	173.23 g/mol
Synonyms	(S)-5-Oxo-2-pyrrolidinecarbothioic acid S-ethyl ester; L-Pyroglutamic acid thioethyl ester; (S)-(-)-2-Ethyl thiopyroglutamate; (2S)-2-(Ethylsulfanyl)-5-oxopyrrolidine-2-carboxylic acid; (S)-Pyroglutamic acid ethyl thioester; (S)-Ethyl 5-oxopyrrolidine-2-carbothioate; (S)-Ethyl 2-mercapto-5-oxo-2-pyrrolidinecarboxylate; (S)-Ethyl pyroglutamothioate
EINECS	Contact for details

Quality Control

Our (2S)-5-Oxo-2-Pyrrolidinecarbothioic Acid S-Ethyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to meet the exacting standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.