Description

1-[3-(Trifluoromethyl)Benzyl]-1H-Imidazole-4-Carboxylic Acid is a high-value trifluoromethylated benzyl imidazole derivative, serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both an imidazole core and a trifluoromethylbenzyl group, makes it an essential intermediate for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in kinase inhibitor and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced fungicides, herbicides, and insecticides where the trifluoromethyl group imparts improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized N-heterocyclic carbene (NHC) ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its aromatic and heterocyclic structure.
• Chemical Biology Probes: Utilized as a core structure for developing molecular probes and diagnostic agents in biochemical research.

Basic Information

Product Name	1-[3-(Trifluoromethyl)Benzyl]-1H-Imidazole-4-Carboxylic Acid
CAS No.	1295542-29-8
Molecular Formula	C12H9F3N2O2
Molecular Weight	270.21 g/mol
Synonyms	1-[(3-Trifluoromethyl)benzyl]-1H-imidazole-4-carboxylic acid; 1-(3-Trifluoromethylbenzyl)-1H-imidazole-4-carboxylic acid; 1H-Imidazole-4-carboxylic acid, 1-[[3-(trifluoromethyl)phenyl]methyl]-; 4-Imidazolecarboxylic acid, 1-[(3-(trifluoromethyl)phenyl)methyl]-; α-(Trifluoromethyl)-1H-imidazole-4-acetic acid derivative; 3-(Trifluoromethyl)benzyl imidazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our production of 1-[3-(Trifluoromethyl)Benzyl]-1H-Imidazole-4-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.