Description

2-Chloro-6-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol is a high-value boronic ester derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing complex phenolic and biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that leverage its unique halogenated phenolic boronate structure.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs and organic semiconductors.
• Ligand and Catalyst Development: Utilized as a precursor for creating novel bidentate or tridentate ligands in transition metal catalysis.
• Chemical Biology Probes: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for imaging and diagnostic applications.
• Academic & Industrial R&D: A fundamental reagent for methodological development in cross-coupling chemistry and the exploration of new chemical space in medicinal chemistry programs.

Basic Information

Product Name	2-Chloro-6-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol
CAS No.	1294518-25-4
Molecular Formula	C₁₃H₁₈BClO₃
Molecular Weight	268.54 g/mol
Synonyms	2-Chloro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; 4-Boronic acid, 2-chloro-6-methylphenol, 1,3,2-dioxaborolane ester; 2-Chloro-6-methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)phenol; Phenol, 2-chloro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1294518-25-4; 2-Chloro-6-methyl-4-(pinacolatoboron)phenol; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-chloro-6-methylphenol
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-6-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenol adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for demanding synthetic applications. All materials are characterized by modern analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.