Description

(R)-4-((3-(Benzyloxy)-2-Hydroxypropyl)Amino)-5-Bromo-2-Fluorobenzenaminium 4-Methylbenzenesulfonate is a high-purity, advanced pharmaceutical intermediate and chiral building block of significant synthetic value. This compound is engineered to provide researchers and manufacturers with a reliable, high-quality starting material for complex organic syntheses, particularly in the development of active pharmaceutical ingredients (APIs). It is primarily utilized by the pharmaceutical, biotechnology, and fine chemical industries for research, process development, and scale-up production.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel therapeutic agents, particularly in medicinal chemistry programs.
• API Development: Serves as a key building block for the research and development of potential Active Pharmaceutical Ingredients (APIs) targeting specific biological pathways.
• Process Chemistry: Used in route scouting, optimization, and scale-up studies within fine chemical and contract manufacturing organizations (CMOs).
• Asymmetric Synthesis: Leverages its chiral (R)-configuration for the construction of enantiomerically pure molecules in academic and industrial research.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Life Science Research: Used in biochemical and pharmacological research to study structure-activity relationships (SAR) and develop new molecular entities.

Basic Information

Product Name	(R)-4-((3-(Benzyloxy)-2-Hydroxypropyl)Amino)-5-Bromo-2-Fluorobenzenaminium 4-Methylbenzenesulfonate
CAS No.	1294504-64-5
Molecular Formula	C23H26BrFN2O5S
Molecular Weight	557.43 g/mol
Synonyms	5-Bromo-2-fluoro-N-[(2R)-3-(phenylmethoxy)-2-hydroxypropyl]-1,4-benzenediamine 4-methylbenzenesulfonate; (R)-4-((3-(Benzyloxy)-2-hydroxypropyl)amino)-5-bromo-2-fluorobenzenaminium p-toluenesulfonate; (R)-5-Bromo-2-fluoro-N1-(3-(benzyloxy)-2-hydroxypropyl)benzene-1,4-diamine tosylate salt; (R)-4-Amino-5-bromo-2-fluoro-N-(3-(benzyloxy)-2-hydroxypropyl)benzenaminium tosylate; 1294504-64-5; Benzenediamine, 5-bromo-2-fluoro-N-[(2R)-3-(phenylmethoxy)-2-hydroxypropyl]-, 4-methylbenzenesulfonate (1:1)
EINECS	Contact for details

Quality Control

Our (R)-4-((3-(Benzyloxy)-2-Hydroxypropyl)Amino)-5-Bromo-2-Fluorobenzenaminium 4-Methylbenzenesulfonate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.