Description

1-(4-Chloro-2-Fluoro-5-Nitro-Phenyl)-Ethanone is a high-purity, multi-functional aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and nitro substituents, makes it a versatile precursor for constructing complex molecular architectures. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and pesticides, leveraging its halogenated nitroaromatic core.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Dye and Pigment Intermediate: Acts as a starting material for synthesizing complex azo dyes and high-performance pigments.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Chemical Research & Development: A valuable reagent for method development and exploring new reaction pathways in academic and industrial laboratories.

Basic Information

Product Name	1-(4-Chloro-2-Fluoro-5-Nitro-Phenyl)-Ethanone
CAS No.	1292836-16-8
Molecular Formula	C8H5ClFNO3
Molecular Weight	217.58 g/mol
Synonyms	1-(4-Chloro-2-fluoro-5-nitrophenyl)ethanone; 4'-Chloro-2'-fluoro-5'-nitroacetophenone; 2-Fluoro-4-chloro-5-nitroacetophenone; Ethanone, 1-(4-chloro-2-fluoro-5-nitrophenyl)-; 4-Chloro-2-fluoro-5-nitroacetophenone; 5-Nitro-4-chloro-2-fluoroacetophenone; Acetophenone, 4-chloro-2-fluoro-5-nitro-; CAS 1292836-16-8
EINECS	Contact for details

Quality Control

Our 1-(4-Chloro-2-Fluoro-5-Nitro-Phenyl)-Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is light-sensitive and should be stored away from light. Handle and store under an inert atmosphere if prolonged storage is required.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.