Description

5-Bromo-n-(1-Methylpiperidin-3-Yl)Pyridine-3-Sulfonamide is a high-purity, advanced pharmaceutical intermediate and research chemical with the CAS registry number 1292400-52-2. This compound is valued for its unique molecular architecture, which incorporates a brominated pyridine core linked to a substituted piperidine ring via a sulfonamide bridge, making it a critical building block for medicinal chemistry research. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of novel bioactive molecules, particularly for applications in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Kinase Inhibitor Development: Serves as a core structure in the design and synthesis of potential kinase inhibitors for oncology applications.
• CNS-Active Compound Synthesis: Employed in the research and development of compounds intended to cross the blood-brain barrier for neurological targets.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological processes and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	5-Bromo-n-(1-Methylpiperidin-3-Yl)Pyridine-3-Sulfonamide
CAS No.	1292400-52-2
Molecular Formula	C11H16BrN3O2S
Molecular Weight	334.23 g/mol
Synonyms	5-Bromo-N-(1-methyl-3-piperidinyl)-3-pyridinesulfonamide; 3-Pyridinesulfonamide, 5-bromo-N-(1-methyl-3-piperidinyl)-; 5-Bromo-N-(1-methylpiperidin-3-yl)pyridine-3-sulfonamide; 1292400-52-2; 5-Br-N-(1-Me-piperidin-3-yl)-Py-3-SO2NH2; 5-Bromo-3-(N-(1-methylpiperidin-3-yl)sulfamoyl)pyridine
EINECS	Contact for details

Quality Control

Our production of 5-Bromo-n-(1-Methylpiperidin-3-Yl)Pyridine-3-Sulfonamide adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research or development specifications. Our quality systems are designed to support both non-GMP and cGMP-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.