Description

2-(Tetrahydro-2H-Pyran-4-Yloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl architectures. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring biaryl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Serves as a versatile coupling partner for the palladium-catalyzed formation of carbon-carbon bonds, essential for constructing complex molecular scaffolds.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to explore new chemical entities for therapeutic potential.
• Agrochemical Synthesis: Employed in the research and development of novel herbicides, fungicides, and insecticides that require specific aromatic structures.
• Material Science Precursor: Can be utilized in the development of organic electronic materials, such as OLEDs or conductive polymers, where precise molecular architecture is needed.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting the outsourced R&D and production needs of global life science companies.

Basic Information

Product Name	2-(Tetrahydro-2H-Pyran-4-Yloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile
CAS No.	1292317-54-4
Molecular Formula	C18H24BNO4
Molecular Weight	329.20 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-[(oxan-4-yl)oxy]benzonitrile; 2-(Tetrahydro-2H-pyran-4-yloxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; THP-Protected Boronic Ester Benzonitrile; 2-(THP-Oxy)-5-Bpin Benzonitrile; 1292317-54-4; 5-Boronic acid pinacol ester-2-(tetrahydropyran-4-yloxy)benzonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-(Tetrahydro-2H-Pyran-4-Yloxy)-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzonitrile is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by NMR)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.