Description

(S)-1-(3,4-Dichloro-Benzyl)-Pyrrolidin-3-Ol CAS NO 1289585-08-5 is a high-purity chiral intermediate featuring a pyrrolidine scaffold substituted with a dichlorobenzyl group. This compound matters as a critical building block in the synthesis of advanced pharmaceutical agents, particularly those targeting the central nervous system. Pharmaceutical R&D and process chemistry teams need it for developing new active pharmaceutical ingredients (APIs) where stereochemical purity is paramount for efficacy and safety.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially in neurological and psychiatric therapeutic areas.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex molecules where the (S)-enantiomer configuration is required for biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in catalytic asymmetric reactions to induce stereoselectivity.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for scale-up and commercial production of proprietary pharmaceuticals.
• Reference Standard: Used as an analytical standard for method development, validation, and quality control in pharmaceutical analysis.

Basic Information

Product Name	(S)-1-(3,4-Dichloro-Benzyl)-Pyrrolidin-3-Ol
CAS No.	1289585-08-5
Molecular Formula	C11H13Cl2NO
Molecular Weight	246.13 g/mol
Synonyms	(S)-1-[(3,4-Dichlorophenyl)methyl]-3-pyrrolidinol; (3S)-1-[(3,4-Dichlorophenyl)methyl]pyrrolidin-3-ol; (S)-1-(3,4-Dichlorobenzyl)-3-hydroxypyrrolidine; (S)-3-Hydroxy-1-(3,4-dichlorobenzyl)pyrrolidine; 1289585-08-5; (S)-enantiomer of 1-(3,4-Dichlorobenzyl)pyrrolidin-3-ol
EINECS	Contact for details

Quality Control

Our (S)-1-(3,4-Dichloro-Benzyl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We support development from milligram to kilogram scale with GMP-compliant documentation available for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.