Description

1,3,2-Dioxaborolane,2-(4-Fluoro-2-Nitrophenyl)-4,4,5,5-Tetramethyl- is a high-purity, functionalized boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring fluorinated aromatic structures.
• Material Science Research: Building block for creating organic electronic materials, such as polymers for OLEDs or organic photovoltaics.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for bio-conjugation and imaging applications.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the (4-fluoro-2-nitrophenyl) moiety.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	1,3,2-Dioxaborolane,2-(4-Fluoro-2-Nitrophenyl)-4,4,5,5-Tetramethyl-
CAS No.	1288978-82-4
Molecular Formula	C12H15BFNO4
Molecular Weight	267.06 g/mol
Synonyms	2-(4-Fluoro-2-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-Fluoro-2-nitrophenylboronic acid pinacol ester; (4-Fluoro-2-nitrophenyl)boronic acid pinacol ester; 2-(4-Fluoro-2-Nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (4-fluoro-2-nitrophenyl)boronate; 4-Fluoro-2-nitrobenzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of our 1,3,2-Dioxaborolane,2-(4-Fluoro-2-Nitrophenyl)-4,4,5,5-Tetramethyl- is manufactured and tested under strict quality management systems. We ensure compliance with the high-purity standards required for research and commercial synthesis. Comprehensive analytical testing, including HPLC, NMR, and LC-MS, is performed to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.