Description

4',5'-Dichloro-2'-Fluoroacetophenone (99%) is a high-purity, multi-halogenated acetophenone derivative serving as a critical building block in advanced organic synthesis. Its precise halogen substitution pattern makes it an invaluable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing aromatic cores in electronic materials, improving charge transport and thermal stability in display technologies.
• Organic Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs), leveraging its halogen handles for further functionalization.
• Chemical Research & Development: A versatile scaffold in medicinal and process chemistry for structure-activity relationship (SAR) studies and route scouting.
• Specialty Polymer Monomer: Potential monomer for high-performance polymers requiring halogenated aromatic units for flame retardancy or specific optical properties.

Basic Information

Item	Details
Product Name	4',5'-Dichloro-2'-Fluoroacetophenone (99%)
CAS No.	1286734-89-1
Molecular Formula	C8H5Cl2FO
Molecular Weight	207.03 g/mol
Synonyms	1-(4,5-Dichloro-2-fluorophenyl)ethan-1-one; 2-Fluoro-4,5-dichloroacetophenone; 4,5-Dichloro-2-fluoroacetophenone; 1-Acetyl-4,5-dichloro-2-fluorobenzene; 4',5'-Dichloro-2'-fluoroacetophenone; 2-Fluoro-4,5-dichlorophenylethanone; (4,5-Dichloro-2-fluorophenyl)methyl ketone
EINECS	Contact for details

Quality Control

Our 4',5'-Dichloro-2'-Fluoroacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.