Description

3-Fluoro-2-[(1-Methylpiperidin-4-Yl)Methoxy]Aniline is a high-value, synthetically versatile aromatic amine building block featuring a unique fluorinated aniline core linked to a substituted piperidine moiety. This compound matters for its role as a critical intermediate in the development of advanced pharmaceutical agents, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to synthesize novel drug candidates, leveraging its structural complexity for creating molecules with specific biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for CNS-targeting drugs, receptor modulators, and kinase inhibitors.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization stages for constructing complex molecular scaffolds with potential therapeutic value.
• Agrochemical Development: Serves as a building block for creating new-generation pesticides and herbicides, where the fluorine atom and aniline group can enhance bioactivity and environmental stability.
• Ligand Synthesis for Catalysis: Employed in the preparation of specialized ligands for asymmetric catalysis and transition metal complexes.
• Material Science Research: Potential monomer or functionalization agent for advanced polymers and functional materials requiring specific electronic or steric properties.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags, affinity probes, or other tools for studying biological systems and target engagement.

Basic Information

Item	Details
Product Name	3-Fluoro-2-[(1-Methylpiperidin-4-Yl)Methoxy]Aniline
CAS No.	1286273-86-6
Molecular Formula	C13H19FN2O
Molecular Weight	238.30 g/mol
Synonyms	3-Fluoro-2-[(1-methyl-4-piperidinyl)methoxy]benzenamine; 2-[(1-Methylpiperidin-4-yl)methoxy]-3-fluoroaniline; 3-Fluoro-2-((1-methylpiperidin-4-yl)methoxy)aniline; 1286273-86-6; 3-Fluoro-2-[(1-methyl-4-piperidinyl)methoxy]aniline; Benzenamine, 3-fluoro-2-[(1-methyl-4-piperidinyl)methoxy]-
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-[(1-Methylpiperidin-4-Yl)Methoxy]Aniline is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (HPLC/MS)	Conforms to structure
Identification (IR)	Conforms to reference
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.