Description

Cyclopropanecarboxylic Acid [4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Amide is a high-value, advanced pharmaceutical intermediate featuring a pyridine core functionalized with a pinacol boronate ester and a cyclopropanecarboxamide group. This compound is specifically designed for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for constructing carbon-carbon bonds. It is an essential building block for research chemists and process development scientists in the pharmaceutical and agrochemical industries, enabling the efficient synthesis of novel, complex molecules for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester group makes this compound an ideal partner for palladium-catalyzed coupling with aryl or heteroaryl halides, enabling efficient library synthesis for medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific heterocyclic architectures.
• Material Science: Serves as a building block for creating organic electronic materials, ligands for catalysts, and advanced polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the construction of bifunctional molecules for targeted protein degradation research.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and process chemistry.

Basic Information

Item	Details
Product Name	Cyclopropanecarboxylic Acid [4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Amide
CAS No.	1286230-87-2
Molecular Formula	C16H23BN2O3
Molecular Weight	302.18 g/mol
Synonyms	2-(Cyclopropanecarboxamido)pyridin-4-ylboronic acid pinacol ester; N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)cyclopropanecarboxamide; 4-(N-Cyclopropanecarboxamido)-2-pyridinylboronic acid pinacol ester; Cyclopropanecarboxamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-; CAS 1286230-87-2; Boronic ester pyridine intermediate; Suzuki coupling reagent pyridine derivative.
EINECS	Contact for details

Quality Control

Every batch of Cyclopropanecarboxylic Acid [4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyridin-2-Yl]-Amide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling reactions and pharmaceutical R&D. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to minimize moisture uptake and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.